Liraglutide (Synonyms: 利拉鲁肽)

目录号: HY-P0014 纯度: 99.85%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Liraglutide 是一种胰高血糖素样肽-1 (GLP-1) 受体激动剂，用于研究 2 型糖尿病。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Liraglutide Chemical Structure

CAS No. : 204656-20-2

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规格	价格	是否有货
1 mg	￥1450	In-stock
5 mg	￥5800	In-stock
10 mg	现货	询价
50 mg		询价
100 mg		询价

or 大包装询价

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Customer Review

Other Forms of Liraglutide:

MCE 顾客使用本产品发表的 22 篇科研文献

: Liraglutide purchased from MCE. Usage Cited in: Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F458-F468. [Abstract]; Representative Western blot showing FN protein abundance in HMCs cultured in media containing 5.5 mM glucose (NG) or 5.5 mM glucose + 19.5 mM mannitol (NG+M) or 25 mM glucose (HG) in the absence or presence of liraglutide at different concentrations (1 nM, 10 nM, 100 nM, 1000 nM) for 24h.

: Liraglutide purchased from MCE. Usage Cited in: Mol Med Rep. 2016 Oct;14(4):3662-8. [Abstract]; Effects of Liraglutide treatment on Alp and OC protein expression levels, and matrix mineralization. Following culture in commercial osteogenic differentiation medium for 14 days, MC3T3-E1 cells are cultured for an additional 14 days in basal culture medium with various concentrations of Liraglutide (0, 0.1, 0.5, 1, 2 and 4 nM). MC3T3-E1 cells maintained in DMEM for 28 days with no treatment are used as the NC; cells cultured in the commercial osteogenic differentiation medium for 14 days and in

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

IC₅₀ & Target

GLP-1 receptor^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	65.7 pM Compound: Liraglutide	Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as induction of cAMP levels after 20 mins by time-resolved fluorescence analysis Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as induction of cAMP levels after 20 mins by time-resolved fluorescence analysis	[PMID: 31471103]
HEK293	EC₅₀	9.3 pM Compound: liraglutide	Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay	[PMID: 24308627]

体外研究
(In Vitro)

Liraglutide 与内源性代谢激素 GLP-1 结合相同的受体。Liraglutide 在 oxLDL 刺激的 Raw264.7 细胞中激活了 AMPK/SREBP1 通路^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

3751.20

Formula

C₁₇₂H₂₆₅N₄₃O₅₁

CAS 号

204656-20-2

性状

固体

颜色

White to off-white

Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-{Lys-N6-[N-(1-oxohexadecyl)-L-g-glutamyl]}-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly

Sequence Shortening

HAEGTFTSDVSSYLEGQAA-{Lys-N6-[N-(1-oxohexadecyl)-L-g-glutamyl]}-EFIAWLVRGRG

中文名称

利拉鲁肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

细胞实验：

0.1 M NaOH 中的溶解度 : ≥ 12.5 mg/mL (3.33 mM)

H₂O 中的溶解度 : 9.52 mg/mL (2.54 mM; adjust pH to 3 with 1 M HCL)

H₂O 中的溶解度 : 5 mg/mL (1.33 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2666 mL	1.3329 mL	2.6658 mL
5 mM	---	---	---
10 mM	---	---	---

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.85%

选择批次：

Data Sheet (602 KB) SDS (252 KB)

COA (283 KB) LCMS (96 KB) 元素分析报告 (205 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9. [Content Brief]

[2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416. [Content Brief]

Cell Assay ^[1]	Raw264.7 macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO₂. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9. [Content Brief] [2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416. [Content Brief]

Cell Assay
^[1]

Raw264.7 macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO₂. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9. [Content Brief]

[2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416. [Content Brief]

Liraglutide 相关分类

Metabolic Disease Cancer

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / 0.1 M NaOH

1 mM

0.2666 mL

1.3329 mL

2.6658 mL

6.6645 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Liraglutide204656-20-2利拉鲁肽GCGRGLP ReceptorGlucagon ReceptorInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Liraglutide (Synonyms: 利拉鲁肽)

Customer Review

Other Forms of Liraglutide:

MCE 顾客使用本产品发表的 22 篇科研文献